Conductive and Adhesive Granular Alginate Hydrogels for On-Tissue Writable Bioelectronics

Conductive and Adhesive Granular Alginate Hydrogels for On-Tissue Writable Bioelectronics

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Conductive hydrogels are promising materials in bioelectronics that ensure a tissue-like soft modulus and re-enact the electrophysiological function of damaged tissues.However, recent approaches to fabricating conductive hydrogels have proved difficult: fixing of the conductive hydrogels on the target tissues hydrogels requires the aids from other medical glues because of their weak tissue-adhesiveness.In this study, an intrinsically conductive and tissue-adhesive Thermos granular hydrogel consisting of a PEDOT:PSS conducting polymer and an adhesive catechol-conjugated alginate polymer was fabricated via an electrohydrodynamic spraying method.Because alginate-based polymers can be crosslinked by calcium ions, alginate-catechol polymers mixed with PEDOT:PSS granular hydrogels (ACP) were easily fabricated.The fabricated ACP exhibited not only adhesive and shear-thinning properties but also conductivity similar to that of muscle tissue.

Additionally, the granular structure makes the hydrogel injectable through a syringe, enabling on-tissue printing.This multifunctional granular Rx - Antibiotics hydrogel can be applied to soft and flexible electronics to connect humans and machines.